Revascularization before exercise program improves walking for patients with PAD
Among patients with peripheral artery disease and intermittent claudication (cramping pain in the legs due to poor circulation in the arteries, aggravated by walking), a combination therapy of...
View ArticleFemale hormone supplements with estrogen and progestin linked to breast...
Postmenopausal African American women who use female hormone supplements containing estrogen and progestin ("combination" therapy) are at an increased risk for estrogen receptor positive breast cancer.
View ArticleGene therapy restores immunity in children and young adults with rare...
Gene therapy can safely rebuild the immune systems of older children and young adults with X-linked severe combined immunodeficiency (SCID-X1), a rare inherited disorder that primarily affects males,...
View ArticleDabrafenib/trametinib in advanced BRAF V600 mutated melanoma: Indication of...
Dabrafenib (trade name: Tafinlar) has been approved since 2013 for the treatment of adults with advanced, i.e. metastatic or unresectable, melanoma with a BRAF V600 mutation. Since September 2015,...
View ArticleSingle-lesion biopsy may be insufficient to choose therapy targeting...
When metastatic tumors driven by drug-targetable genetic mutations become resistant to a targeted therapy drug, the usual practice is to biopsy a single metastatic lesion to test for new mutations that...
View ArticleResearchers find tough new obstacle to HIV cure strategies
(Medical Xpress)—It's a good news/bad news scenario: Researchers have made a new discovery about HIV that will redirect curative strategies toward latent reservoirs of HIV—that's the good news. The bad...
View ArticleResults of Raltegravir plus combination antiretroviral therapy in early HIV...
Addition of the integrase strand transfer inhibitor raltegravir (RAL) to standard antiretroviral therapy (ART) in ART-naive patients with early HIV infection was not associated with a difference in the...
View ArticleCombination therapy may be better than radiotherapy alone to treat aggressive...
Radiotherapy effectively damages brain tumors but the cancer cells can repair themselves in order to live on. Now, researchers at Sidney Kimmel Cancer Center have tested a strategy that combines...
View ArticleScientists work to bring about a new treatment for rare childhood cancer
Neuroblastoma is a rare cancer that develops in very early forms of nerve cells in the embryo or fetus, and it accounts for the most pediatric deaths for any tumor outside of the brain. The most lethal...
View ArticleDabrafenib / trametinib: Considerable added benefit for men with advanced...
Dabrafenib (trade name: Tafinlar) has been approved since 2013 for the treatment of adults with advanced, i.e. metastatic or unresectable, melanoma with a BRAF V600 mutation. Since September 2015,...
View ArticleCurbing malaria resistance with multiple therapies
In order to preserve first-line drugs for treating malaria, multiple combination therapies should be deployed within a population to prevent resistance from developing, according to Maciej Boni from...
View ArticleNew platform optimizes drug doses to prevent organ rejection for transplant...
For decades, doctors and scientists have predicted that personalized medicine—tailoring drug doses and combinations to people's specific diseases and body chemistry—would be the future of health care.
View ArticleHIV infection prematurely ages humans by an average of five years
Thanks to combination antiretroviral therapy, many people with HIV can be expected to live decades after being infected. Yet doctors have observed that these patients often show signs of premature...
View ArticleResearchers develop novel, non-toxic approach to treating variety of cancers
A team of researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine recently discovered a novel, non-toxic approach to treating a wide variety of...
View ArticleCombination therapy cures tick-borne illness in mice
A novel combination therapy cures an emerging infectious disease, babesiosis, which is transmitted by the same ticks that transmit the agents of Lyme disease, said Yale researchers. This "radical"...
View ArticleResearchers create genetic blueprint of cunning tuberculosis bacteria
The rise in multi-drug resistant (MDR) and extremely drug resistant (XDR) strains of Mycobacterium tuberculosis (MTB) is becoming a major cause of global health concern for treating tuberculosis, which...
View ArticleNovel combination therapy shows strong response in phase 1 trial
A phase 1 clinical trial testing a novel combination therapy developed by scientists at VCU Massey Cancer Center slowed the growth of cancer in the majority of trial participants, which were patients...
View ArticleEarly antiretroviral therapy reduces gut inflammation in HIV+ individuals
Combination antiretroviral therapy (cART) suppresses HIV replication and significantly slows the progression of disease, enabling HIV+ individuals to effectively manage infection for long periods. One...
View ArticleCombining biologic and phototherapy treatments for moderate-to-severe psoriasis
The review, entitled "Combining biologic and phototherapy treatments for psoriasis: safety, efficacy, and patient acceptability," was carried out by a group of researchers in the USA. They conducted an...
View ArticleRamucirumab in stomach cancer: Added benefit not proven
Ramucirumab (trade name: Cyramza) is a monoclonal antibody, which blocks a receptor, reducing the growth of blood vessels and so reducing blood supply to the tumours. This aims to slow the growth of...
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